Dynamic Prediction of Treatment Response in Late-Life Depression

Neurocognitive correlates of response to treatment in late-life depression.

UNLABELLED Depression is often associated with neurocognitive deficits in older adults, particularly in the domains of information processing speed, episodic memory, and executive functions. Greater neurocognitive dysfunction while depressed is associated with a less effective treatment response; however, questions remain about the specific variables that characterize patients showing low treat...

MULTIMODAL MR PREDICTION MODELS FOR LATE-LIFE DEPRESSION AND TREATMENT RESPONSE by

Treatment of depression in late life

Depression is a common problem in older patients and a significant contributor to morbidity and mortality in this population. The identification and treatment of depression is more complex in older patients because of difficulty in diagnosis, coexisting illnesses, and concurrent drug therapy. In addition, a variety of medical conditions and drugs can cause depression. Treatment often has to be ...

Treatment-resistant depression in late life.

Treatment resistance is reported in up to 40% of older patients with major depression. Before labeling an episode of depression as treatment resistant, it is important to ensure that the diagnosis is correct and that the patient has received and adhered to an adequate dose of treatment for an appropriate length of time. It is also important to assess the patient for comorbid physical and psychi...

Review of treatment for late-life depression

Late-life depressive disorder, occurring in those over the age of 60 years, is common, affecting over 9% of people living in the community (Beekman 1999; McDougall 2007) and 25% of those living in institutions (McDougall 2007). It is associated with reduced quality of life and high morbidity (Alexopoulos 2009a; Volicer 2012). It has a detrimental impact on recovery from physical illness (patien...